Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus

There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in pathogenesis lichen planus (LP). The goal this study to detect desmoglein-3 auto-antibodies patients comparted normal control persons via investigating its potential disease. A case for detection Desmoglein-3 autoantibodies serum 40 and healthy controls using enzyme-linked immunosorbent assay (ELISA) technique.The were recruited from Dermatology outpatient clinic at Beni-Suef University hospital. measurement anti Dsg3 antibodies LP was significantly higher as compared persons. mean scores 1361.37 ± 300.5 oral & 2118.70 584.37 cutaneous vs. 66.98 ±70.95 (p-value < 0.001). may have a Further investigations are needed Dsg skin biopsy or blood samples by other methods such Immunofluorescence.